Team Firsts
- First Regular Season Game
- New York Titans/Jets; loss 27-3 9/11/60
- First Winning Season
- (7-6-1) 1961
- First Player elected to Hall of Fame
- O.J Simpson, RB 1985
- Most Career Rushing Yards
- Thurman Thomas (11,938 yards)
- Most Career Passing Yards
- Jim Kelly (35,467 yards)
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Bills Hall of Fame
- Eddie Abramoski
- Joe DeLamielleure
- Elbert Dubenion
- Joe Ferguson
- Kent Hull
- Robert James
- Bob Kalsu
- Jim Kelly
- Jack Kemp
- Marv Levy
- Patrick J. McGroder
- George Saimes
- Tom Sestak
- Billy Shaw
- O.J. Simpson
- Fred Smerlas
- Mike Stratton
- Darryl Talley
- Ralph Wilson
- The 12th Man – the fans
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- Joe DeLamielleure
- Jim Kelly
- O.J. Simpson
- Marvy Levy
- Billy Shaw
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